What Can the PICSI Dish Do for You?

Easy Picking!

PICSI® Sperm Selection Device gives the Embryologist an ideal tool to distinguish the mature hyaluronan-binding sperm from immature non-binders. Selecting sperm bound to hyaluronan is most important when your reproductive specialist recommends ICSI (intracytoplasmic sperm injection) for your treatment. In this treatment, an individual sperm is captured and injected into the egg to fertilize it. Without the PICSI device, sperm are chosen based only on appearance and motility. Visual assessment alone should never be the only factor involved when selecting a sperm for ICSI. Unexplained pregnancy loss, can be due to the fact that the sperm selected in the ICSI process was immature and had compromised DNA integrity. Using the PICSI device, the chosen sperm not only look good and are motile but they are able to bind to hyaluronan. The binding sperm are more mature and have less DNA damage than non-binding sperm.

Sperm with benefits!
A recent study compared hyaluronan-binding sperm to motile sperm in ICSI patients with low binding scores. Those who received the PICSI-selected sperm were more likely to get pregnant compared to their counterparts. More importantly, among the control (non-PICSI) patients, 15% of the pregnancies detected by the presence of a fetal sac never developed a fetal heart beat. Among the PICSI group, none of the pregnancies detected by the presence of a fetal sac were lost – all of them developed a fetal heart beat. This remarkable reduction in the loss of pregnancy accounts in part for the improved overall pregnancy rate seen in the PICSI group.
The study explained the improved pregnancy rates by showing that the embryos created with hyaluronan-binding sperm exhibited greater viability. They had less fragmentation and better cell growth on day 3 and better blastocyst formation on day 5. A newer report from the Society of Assisted Reproductive Technology (SART) analyzed a large embryo morphology database and confirmed that the quality of the day 3 embryo relates directly to live birth rate2 – better embryos yield higher birth rates and PICSI-derived zygotes deliver better embryos.

2. Racowsky C; Stern JE; Gibbons WE; Behr B; Pomeroy KO; Biggers JD. National collection of embryo morphology data into Society for Assisted Reproductive Technology Clinic Outcomes Reporting System: associations among day 3 cell number, fragmentation and blastomere asymmetry, and live birth rate. Fertility and Sterility 2011; 95 (6): 1985-9.